It tells the story of two people trying to heal the wounds of their past, embarking on a new journey in the magical atmosphere of New York. Serin and Mehmet, who meet by chance, arrive at a turning point in their lives. Burdened by the shadows of the past, heartbreak, and regrets, these two individuals hold on to each other in the heart of New York with the hope of making a fresh start.

However, their time is limited, and this final call will change everything. Last Call for Istanbul reveals the drama of a passionate love, intersecting lives in an unforgettable city, and the choices that shape their destiny.